Neutrophils Macrophage Phagocytosis of Apoptotic Surfactant Protein A Enhances Alveolar
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Poractant alfa (Curosurf®) increases phagocytosis of apoptotic neutrophils by alveolar macrophages in vivo
BACKGROUND Clearance of apoptotic neutrophils in the lung is an essential process to limit inflammation, since they could become a pro-inflammatory stimulus themselves. The clearance is partially mediated by alveolar macrophages, which phagocytose these apoptotic cells. The phagocytosis of apoptotic immune cells by monocytes in vitro has been shown to be augmented by several constituents of pul...
متن کاملSurfactant protein A enhances apoptotic cell uptake and TGF- 1 release by inflammatory alveolar macrophages
Reidy, Michael F., and Jo Rae Wright. Surfactant protein A enhances apoptotic cell uptake and TGF1 release by inflammatory alveolar macrophages. Am J Physiol Lung Cell Mol Physiol 285: L854–L861, 2003. First published June 6, 2003; 10.1152/ajplung.00439.2002.—The phagocytosis of apoptotic inflammatory cells by alveolar macrophages (AMs) is a key component of inflammation resolution within the a...
متن کاملSurfactant protein A enhances apoptotic cell uptake and TGF-beta1 release by inflammatory alveolar macrophages.
The phagocytosis of apoptotic inflammatory cells by alveolar macrophages (AMs) is a key component of inflammation resolution within the air space. Surfactant protein A (SP-A) has been shown to stimulate the phagocytosis of apoptotic neutrophils (PMNs) by normal AMs. We hypothesized that SP-A promotes the resolution of alveolar inflammation by enhancing apoptotic PMN phagocytosis and anti-inflam...
متن کاملSurfactant protein D reduces alveolar macrophage apoptosis in vivo.
Surfactant protein D (SP-D) is a molecule of the innate immune system that recognizes the patterns of surface carbohydrate on pathogens and targets them for phagocytosis and killing. SP-D-deficient mice show an increased number of macrophages in the alveolar space, excess surfactant phospholipid, overproduction of reactive oxygen species, and the development of emphysema. We report here that SP...
متن کاملSurfactant protein A enhances alveolar macrophage phagocytosis of a live, mucoid strain of P. aeruginosa.
In this study, we investigate the interaction between surfactant protein A (SP-A) and a live, mucoid strain of Pseudomonas aeruginosa and identify a mechanism of clearance of this organism by alveolar macrophages. (125)I-labeled SP-A bound live, but not heat-killed, P. aeruginosa organisms in a concentration-dependent manner. Unlabeled SP-A bound live bacteria, protein isolated from whole organ...
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